卵胞浆内单精子注射技术(intracytoplasmic sperm injection, ICSI)）完全或不完全受精失败非常罕见，但是部分患者由于精子缺乏激活卵母细胞的物质而导致ICSI反复的完全或不完全受精失败。本文报道的是一例严重的弱畸精子患者，出现了反复的ICSI不完全受精失败。在患者的第二个ICSI周期中，10枚卵母细胞经ICSI技术受精后，仅有一枚卵母细胞受精。遂采用钙离子载体A23187对ICSI未受精卵母细胞进行激活处理。未受精卵母细胞激活，获得胚胎，移植后获得临床妊娠，并健康新生儿的出生。由此可见，对ICSI未受精卵母细胞实施“补救性卵母细胞激活技术”能挽救ICSI完全或不完全受精失败。北京大学人民医院计划生育与生殖医学科鹿群

[Abstract]

Total or near-total fertilization failure after intracytoplasmic sperm injection (ICSI) is a rare event, but it occurs repeatedly because of sperm defects in activating oocyte. The case presents a successful pregnancy and live birth after calcium ionophore A23187 (A23187) activation on one-day-old unfertilized oocytes in a patient whose husband suffered oligoasthenoteratozoospermia, and who had experienced repeated near-total fertilization failure after ICSI. In the second ICSI cycle, only one oocyte was fertilized while nine were unfertilized. Oocyte activation with A23187 were performed on the one-day-old unfertilized oocytes after ICSI and resulted in fertilization and embryo transfer. A clinical pregnancy was achieved and a healthy baby was born. To our knowledge, this is the first reported case of a healthy birth after oocyte activation on the one-day-old unfertilized oocyte. This indicates that “rescue oocyte activation” on one-day-old unfertilized oocytes after ICSI may be help for preventing total or near-total fertilization failure after ICSI.

Chin Med J 2012;125(3):546-548

性激素替代治疗(HRT)邮应用外源性雌二醇可缓解雌激素缺乏的症状，可预防雌激素长期缺乏导致的骨质疏松和心脑血管疾病，俄罗斯试管婴儿中心同时即便是HRT所使用的足量雌二醇，也不能抑制POF女性卵泡活性和避孕，因此不会阻碍自然妊娠。